Assesing Prostate Cancer Growth with Intact Tissue MRS and mRNA of Spermine Anabolic Enzymes
نویسندگان
چکیده
L. L. Cheng, D. Kaul, C-L. Wu, C. Adkins, K. Jordan, P. Habbel, R. Peterson, W. McDougal, and U. Pohl Radiology/Pathology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, United States, Pathology/ Center for Anatomy, Institute of Cell Biology and Neurobiology, Massachusetts General Hospital/Charite Universitatsmedizin, Pathology/Urology, Massachusetts General Hospital, Pathology, Massachusetts General Hospital, Center for Anatomy, Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin, Medicine, Massachusetts General Hospital, Urology, Massachusetts General Hospital
منابع مشابه
Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens.
Using Northern blotting, the expression levels of the genes for polyamine metabolism regulatory proteins and clusterin have been measured in a series of 23 human prostate cancers (CaPs) dissected from radical prostatectomy specimens. Patient matched, nontumor tissue was dissected from benign areas of the gland. The results indicate that transcripts encoding ornithine decarboxylase (ODC), ODC an...
متن کاملبررسی ارتباط نسبت مجموع کولین و کراتین به سیترات در Magnetic resonance spectroscopy با میزان تهاجم تومور در سرطان پروستات
Background: Prostate cancer is the most common cancer and the second cause of cancer mortality in men. Although histopathological examination is the gold-standard for its diagnosis, tendency toward less invasive methods is growing. The purpose of this study was to evaluate the relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy (MRS) with the invasion...
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The relationship between polyamine synthesis, growth and secretion in vivo was examined in ventral prostates from: (a) intact rats aged 3-60 weeks; (b) animals castrated for 7 days before injection with 5r-dihydrotestosterone (17,8-hydroxy-5a-androstan-3-one), testosterone and 5 r-androstane-3,8,17,f-diol for up to 10 days; (c) rats injected with the 3fi,17fidiol immediately after castration. O...
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Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...
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Background and Aims: Prostate cancer is the second most common cancer in men worldwide in men. Matrix metalloproteinase 2 (MMP2) has a role in the invasion and destruction of the basement membrane and the extra-cellular matrix and facilitating the process of tumor cell invasion. The present study was conducted to compare the expression of MMP2 gene in prostate cancer (PCa) and benign prostatic ...
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